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-Another very unique feature of this insulin 
is the flexible dosing that can be achieved 
due to it’s extended duration of action -During 
pre-clinical trials, the company conducted 
a couple studies in which patients administered 
insulin degludec on a rotating schedule, 
as shown here, which the patient would rotate 
between taking their dose in the morning 
one day followed by the evening the next. 
-So throughout the week they would take about 
half their doses 8 hours apart and about 
half their doses 40 hours apart. -In this 
study, when given on this flex dosing schedule, 
degludec produced the same A1C lowering without 
increase in hypoglycemia or adverse effects 
compared with standard once daily degludec 
or once daily Lantus. [CLICK] -As a result, 
degludec can actually be given at any time 
of the day, as long as the patient waits 
at least 8 hours for the next dose and does 
not go more than 40 hours between doses, 
 -So that means that if a patient forgets 
or is unable to take their dose at their 
normal time, they don’t have to just skip 
their basal insulin for the day -instead, 
they can feel safe just taking it whenever 
they remember they missed their dose -So 
for example, as this picture shows, if they 
typically take their degludec every morning, 
but one day they forget to take it before 
work for example and miss their morning dose, 
they can just go ahead and take it in the 
evening when they get home -So, this may 
be a great drug for patients who have really 
flexible schedules or patients who often 
struggle with missed doses