-Another very unique feature of this insulin is the flexible dosing that can be achieved due to it’s extended duration of action -During pre-clinical trials, the company conducted a couple studies in which patients administered insulin degludec on a rotating schedule, as shown here, which the patient would rotate between taking their dose in the morning one day followed by the evening the next. -So throughout the week they would take about half their doses 8 hours apart and about half their doses 40 hours apart. -In this study, when given on this flex dosing schedule, degludec produced the same A1C lowering without increase in hypoglycemia or adverse effects compared with standard once daily degludec or once daily Lantus. [CLICK] -As a result, degludec can actually be given at any time of the day, as long as the patient waits at least 8 hours for the next dose and does not go more than 40 hours between doses, -So that means that if a patient forgets or is unable to take their dose at their normal time, they don’t have to just skip their basal insulin for the day -instead, they can feel safe just taking it whenever they remember they missed their dose -So for example, as this picture shows, if they typically take their degludec every morning, but one day they forget to take it before work for example and miss their morning dose, they can just go ahead and take it in the evening when they get home -So, this may be a great drug for patients who have really flexible schedules or patients who often struggle with missed doses