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Biomedical Model explains that,

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The coordination in our brain is lost. As 
some parts have shrunk while some are normal.

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It's like a chariot with 12 horses, when 
one falls sick the smooth functioning is 
lost.

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The interaction between the neurons is decreased. 
The production of new neurons is stopped. 
Which is also called the Loss of Neuroplasticity

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The ability to learn new things, build new 
connections is lost. Which leads to loss 
of memory

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The neurotransmitters lose their melody or 
symphony. It's like a  symphony orchestra 
of 128 artists, Even if one player plays 
badly the whole symphony is lost.

